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br Discussion Before comparing our results with structural s
2021-02-22

Discussion Before comparing our results with structural studies, we can turn to the Wiki on transition state theory (1935), which explains the reaction rates of elementary chemical reactions in terms of two parameters in one dimension. Structural studies contain information on the ground state, a
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Related with the studies by Zizza et al
2021-02-22

Related with the studies by Zizza et al. described above [66], work by Ward et al. [68] suggested that the C2 domain of cPLA2α, which binds to zwitterionic membranes with high affinity in a Ca2+-dependent manner, has a high membrane remodeling activity, producing dramatic changes in membrane curvatu
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Recoverin is a kDa retinal protein that
2021-02-22

Recoverin is a 23-kDa retinal protein that binds to calcium. It regulates the ion channels of rhodopsin during visual transduction within photoreceptor cells. Since the pathogenicity of anti-recoverin antibody is potent, anti-recoverin CAR patients often have progressive visual impairments, charact
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br Activity based probes br Characterization of
2021-02-22

Activity-based probes Characterization of coronavirus-encoded DUBs with activity-based probes To study the activity of specific DUBs, investigators frequently take advantage of the ~10kDa (monoUb or Ubl ABP) or ~20kDa (DiUb ABP) increase in MW on probe labeling. SDS-PAGE analysis or blotting f
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G DH has gained interest because
2021-02-22

G3DH has gained interest because of its broad substrate specificity and site-selective oxidation properties [9,10]. The conversion product, 3-ketoglycoside, possesses potential as a starting material for the chemical industry such as in polymer and surfactants because the keto group becomes a specif
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POE specialises Rogers definition of engineering to systems
2021-02-20

POE specialises Rogers' definition of engineering [37] to systems engineering as: As such, systems engineering becomes a problem solving exercise, the problem being, given a physical environment E, to find the system S that GW441756 meets a real-world need N to the satisfaction of a group of stake
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Some limitations of this study
2021-02-20

Some limitations of this study must be noted. First, since the pretransplant evaluation of the T-cell immune response was performed just before transplantation, we cannot establish whether samples obtained at different times before the transplant would offer similar results, since end terminal disea
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For this study we have used the intermediate affinity mutant
2021-02-20

For this study we have used the intermediate affinity mutant antigen HEL2× for immunization. However, we have observed a similar defect in the plasmablast differentiation of EBI2-deficient SWHEL Sodium Aescinate over a 10,000-fold affinity range by using WT HEL or the low-affinity mutant HEL3× (dat
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br Methods br Results br Discussion Preclinical data indicat
2021-02-19

Methods Results Discussion Preclinical data indicate that nepicastat modulates sympathetic drive to the bifonazole with a mild pressor effect in various animal models of hypertension (Stanney et al., 1998). However in this clinical study, the doses of nepicastat employed did not significan
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Although the ferromagnetic particles and T DNA ligase
2021-02-19

Although the ferromagnetic particles and T4 Berberine Sulfate on the particles were heated by the ac magnetic field, the average temperature of the reaction solution as a whole was kept suitably low for the annealing of DNA ends (16°C). Indeed, no appreciable increase in the temperature of the reac
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In Senegal malaria remains a formidable public health issue
2021-02-19

In Senegal, malaria remains a formidable public health issue, causing significant morbidity and mortality in infants and pregnant women (WHO Malaria Report, 2012). In the absence of an effective vaccine, the National Malaria Control Program has followed WHO recommendations for IPTp-SP since 2003. Th
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The only reported synthesis of the aminobicyclic core
2021-02-19

The only reported synthesis of the aminobicyclic core of is based on bis-alkylation of a 4-amino-5,6-dihydroxypyrmidine with dibromoethane. The likelihood of poor regiocontrol/reactivity in utilizing such a transformation for the synthesis of compounds with a substituent on the dioxinyl ring led us
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Despite its significance in tumor suppression
2021-02-19

Despite its significance in tumor suppression, the molecular mechanism by which DAPK is regulated and its interplay with other tumor suppressors and oncoproteins have not been completely unraveled. Although primarily regulated by CaM binding (Cohen et al., 1997), DAPK activity can also be modulated
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Despite its significance in tumor suppression
2021-02-19

Despite its significance in tumor suppression, the molecular mechanism by which DAPK is regulated and its interplay with other tumor suppressors and oncoproteins have not been completely unraveled. Although primarily regulated by CaM binding (Cohen et al., 1997), DAPK activity can also be modulated
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br In patients with type I
2021-02-19

In patients with type I diabetes mellitus poor management causes/INS; a drastic rise in glucose levels resulting in diabetic ketoacidosis (DKA). About 1% of DKA episodes can be complicated by cerebral edema. ET and its receptors are involved in the regulation of /INS;cerebral blood flow. We studie
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