• EphB appears to be a low affinity receptor for

  2021-02-01

  

  EphB4 appears to be a low-affinity receptor for rhEpo based on the biochemical data. The concentration of rhEpo used for the biological experiments (50 IU/ml) corresponds to 10–15 nM, which is 1% to 2% of the KD value (KD = 881 nM) for the binding of rhEpo to EphB4, as measured in the MST assay. The

• In vitro studies suggest that cPLA does not show clear

  2021-02-01

  

  In vitro studies suggest that cPLA2α does not show clear preference for the headgroup present at the sn-3 position, although a slight preference for zwitterionic phospholipids such as PC and PE has recently been pointed out [24]. In this regard, mass spectrometry analyses of glycerophospholipid hydr

• In our opinion the precise function

  2021-02-01

  

  In our opinion, the precise function of AE of S. mansoni (Sm32) remains unclear, and accurate knowledge of the three dimensional structure of this enzyme would be valuable for a better understanding the molecular basis of many of its properties, including its role in the host-parasite interaction, a

• Methods br Results br Discussion It is well

  2021-02-01

  

  Methods Results Discussion It is well established that CRSwNP is characterized by TH2 inflammation and eosinophilia.22, 27 Yet it is becoming increasingly apparent that B cells might play an important role in the inflammatory response within the sinus tissue of patients with CRSwNP.8, 9 The l

• br EBV Infection Epstein Barr virus EBV

  2021-02-01

  

  EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt's lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). Th

• br RING dimerization RING type

  2021-02-01

  

  RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain (+)-Apogossypol (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF4, BIRC

• In conclusion our results demonstrate

  2021-02-01

  

  In conclusion, our results demonstrate that CCLP promoted osteoblast proliferation, differentiation, and mineralization via activation of ERK, p38, and Smad1/5/8 (Fig. 9). The residues of the GGKQNVGFGP-sequence in CCLP showed the highest significant binding relationship with the target activin rece

• The fact that the mean tumor

  2021-02-01

  

  The fact that the mean tumor size of the E1202-654 + α-GalCer group was much smaller than that of the α-GalCer inoculated group in both protocols indicates that immunization with E1202-654 plus α-GalCer, which induces a strong CD8+ T cell E1 antigen-specific immune response, is involved in the elimi

• Organ fibrosis is thought to

  2021-01-30

  

  Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial Erythromycin induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells activate the pro

• Altered brain insulin signaling and CNS hypometabolism are a

  2021-01-30

  

  Altered D-Luciferin sodium salt receptor insulin signaling and CNS hypometabolism are also associated with pathogenesis of neurodegeneration. Insulin receptors are mostly located in the cerebral cortex, hippocampus, cerebellum, hypothalamus and olfactory bulb, possess an effective role in the regul

• PGE EP activation has been found to

  2021-01-30

  

  PGE2-EP4 activation has been found to attenuate the activation of microglia and to prevent lipid peroxidation and pro-inflammatory gene expression in a murine model of lipopolysaccharide (LPS)-induced 1,4-DPCA inflammation [15]. Moreover, PGE2/EP4 signaling has elicited a protective function in red

• br Halogenases Enzymatic C H activation leading to halogenat

  2021-01-30

  

  Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical

• br In some but not all human vessels

  2021-01-30

  

  In some, but not all, human vessels, a small population of ETB (usually effect on blood pressure or renal hemodynamics, which might have been expected if ETB contributed significantly to a contractile response. Whether the proportion of vascular ETB changes with disease remains controversial and

• The activity of cysteine endopeptidases involved in the

  2021-01-30

  

  The activity of cysteine endopeptidases involved in the germination of caryopses is generally regulated at two levels: the hormonal induction of synthesis by gibberellins (Drzymała et al., 2008) and a putative regulation of activity by phytocystatines (Kiyosaki et al., 2007, Martinez et al., 2009),

• In this study Oncomine GEO and TCGA databases were

  2021-01-30

  

  In this study, Oncomine, GEO and TCGA databases were used to analyze the expression of UBE2S gene in HCC and normal liver tissues to determine the relationship between UBE2S expression and prognosis of hepatocellular carcinoma. The potential function of UBE2S in HCC was analyzed by screening UBE2S c

14255 records 693/951 page Previous Next First page 上5页 691692693694695 下5页 Last page