• br Materials and Methods br Acknowledgements br Introduction

  2020-10-05

  

  Materials and Methods Acknowledgements Introduction The extracellular matrix (ECM) is a dynamic structure that acts as a scaffold for the mechanical support of multicellular organisms. It is responsible for the organisation of different tissues and regulates critical events in development a

• Although many neurotransmitters e g catecholamines serotonin

  2020-10-03

  

  Although many neurotransmitters (e.g., catecholamines, serotonin, and excitatory/inhibitory amino acids) have been implicated in the modulation of anxiety-like responses (Carobrez et al., 2001, Molchanov and Guimaraes, 2002, Vianna et al., 2001), the so-called atypical neurotransmitters, endocannabi

• br Overall system architecture In this section we provide a

  2020-10-02

  

  Overall system architecture In this 3466 section we provide a description of the system under study, and its surrounding environment, on an “as is” basis. The architecture presented in the following is the one currently adopted on-field by ASTS (e.g., at Rome train station). The Train Managemen

• Peptides undergoing only a single hydroxylation i e PA Hyp

  2020-10-02

  

  Peptides undergoing only a single hydroxylation, i.e. PA-Hyp-KPAPK and PAPK-Hyp-APK, were then used to investigate the kinetics of vCPH co-factor and co-substrate dependences. The values for KMapp for Fe(II) and KM for 2OG for the two peptide substrates were within error (KMapp, Fe(II): 0.9 μM ± 0.1

• In the present study we investigated the deeper

  2020-09-30

  

  In the present study, we investigated the deeper role of eNOS in the pathogenesis of nasal polyps and analyzed the influence of 1,8-cineol on nasal polyp gene and protein expression of eNOS in vitro. Different studies dealt with the localization and expression of eNOS in nasal polyps and nasal mucos

• Overall the evidence and the results from in vivo studies

  2020-09-30

  

  Overall, the evidence and the results from in vivo studies clearly indicate that cyclosporine biotransformation can be induced by dasatinib co-administration through induction of CYP3A expression. However, further studies are needed to explore the role of P-gp modulation in DDIs. Conclusion In v

• Bcl Family Set I br Significance Dysregulation of dopamine h

  2020-09-30

  

  Significance Dysregulation of dopamine homeostasis contributes to Parkinson\'s disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of Bcl Family Set I governing the synthesis, packaging, and reuptake of dopamine. Efforts to capitali

• faah inhibitors Various domains of DDR have been shown to

  2020-09-29

  

  Various domains of DDR1 have been shown to be important for receptor clustering and its oligomeric status. It is now understood that (i) dimerization [7] and higher-order oligomerization [12], [18] of the DDR1 extracellular domain (ECD) enhance its binding to collagen; (ii) DDR1 exists as non-covale

• Consistent with prior reports this study also found the

  2020-09-29

  

  Consistent with prior reports, this study also found the level of 11 cytokines (MIF, IL-1Ra, CTACK, M-CSF, Basic FGF, VCAM-1, SDF-1α, IL-8, IL-16, PDGF-β, and GRO-α) significantly decreased in the sera of adult HFMD patients in comparison with controls. MIF is a pro-inflammaory cytokine that is asso

• SB742457 br Fragment based drug discovery

  2020-09-29

  

  Fragment-based drug discovery (FBDD) is a powerful method to discover drug leads and has been widely adopted in both academia and industry. FBDD can be used to explore chemical SB742457 space with libraries which are smaller in size, producing drug leads with high ligand-binding efficiency. It al

• br Funding This work was supported by

  2020-09-29

  

  Funding This work was supported by grants to A.S. from the Swedish Cancer Foundation, Sweden (Grant number: CAN, 2015/637), the Swedish Medical Council, Sweden (Grant number: 2017- 01274), the Foundations at Skåne University Hospital, Sweden and to KB, SRS, NC, BCS, and SS from the Royal Physiogr

• To date the role of CRF and

  2020-09-29

  

  To date, the role of CRF and CRF1+ neurons within the amygdala in the expression of anxiety-like behavior and conditioned fear, and the place where these cell populations fit into the fear-related microcircuitry already identified in the CeA, have not been fully characterized. Recent evidence suppor

• Under conditions of energy scarcity or nutritional restricti

  2020-09-29

  

  Under conditions of energy scarcity or nutritional restriction, AMPK, a critical energy sensor, is activated in response to the increased ratio of AMP to ATP. Various kinases may phosphorylate AMPK, leading to its activation. For example, AMPK phosphorylation by liver kinase B 1 (LKB1) at Thr172 res

• It was recently reported that a

  2020-09-29

  

  It was recently reported that a functional single nucleotide polymorphism (rs75932628) within Triggering receptor expressed on myeloid dapivirine receptor 2 (TREM2) is associated with AD (Guerreiro et al., 2013). Homozygous loss of function mutations in TREM2 are also associated with an autosomal re

• br Methods and materials br Cyclooxygenase COX

  2020-09-29

  

  Methods and materials Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic Dehydroandrographolide to prostaglandin, prostacyclins and thromboxanes., , , Two distinct isoforms of COX were initially discovered: COX-1 is a constitutive, housekeeping enzyme that is expr

14254 records 759/951 page Previous Next First page 上5页 756757758759760 下5页 Last page